The caspase inhibitor z-VAD would not reverse the bafilomycin A1-induced depletion of cytochrome c in mitochondria but this depletion of cytochrome c was turned by the ubiquitination inhibitor MG132, suggesting that bafilomycin A1 induces destruction of cytochrome c in mitochondria which this destruction is delicate to ubiquitination inhibition (Figure 3M)
The caspase inhibitor z-VAD would not reverse the bafilomycin A1-induced depletion of cytochrome c in mitochondria but this depletion of cytochrome c was turned by the ubiquitination inhibitor MG132, suggesting…