Consequently, optimizing interactions between this mobile loop and future Hsp90 inhibitors could provide higher affinity binding inhibitors as has been observed for the morpholino- and monoethylamide-group of NVP-AUY922 (pdb 2VCI)
Consequently, optimizing interactions between this mobile loop and future Hsp90 inhibitors could provide higher affinity binding inhibitors as has been observed for the morpholino- and monoethylamide-group of NVP-AUY922 (pdb 2VCI).…