Formulation with nanoparticles and adjuvant can induce stronger immune responses of vaccines than adjuvant alone, due to enhanced permeability and retention (EPR) effect of nanoparticles in the tumor [102], the depot effect (retention of liposomes and antigens at the injection site as mentioned for the DPX-Survivac vaccine), and selective targeting of tumor-associated but not normal macrophages [42]
Formulation with nanoparticles and adjuvant can induce stronger immune responses of vaccines than adjuvant alone, due to enhanced permeability and retention (EPR) effect of nanoparticles in the tumor [102], the…