Similarly for CYP2D6, the PBPK model provided excellent predictions for mexiletine in both EM and PM subjects, with a slight underprediction of drug clearance with multiple dosing in EM subjects
Similarly for CYP2D6, the PBPK model provided excellent predictions for mexiletine in both EM and PM subjects, with a slight underprediction of drug clearance with multiple dosing in EM subjects.…