Based on the central role of NK and CD8 T cell signaling in cholangiocyte injury and on the increased expression of perforin and granzymes in livers of patients with biliary atresia [10, 11], we hypothesized that this perforin-granzyme system is required for epithelial injury of bile ducts
Based on the central role of NK and CD8 T cell signaling in cholangiocyte injury and on the increased expression of perforin and granzymes in livers of patients with biliary…